Raltegravir

Raltegravir Mustafa Khan Mahwish Khan Ted French Alex Liu BMED 3600 Final Project stand for Use and Mechanism On October 2007, the U.S fare and Drug Administration (FDA) authorize the uptake of raltegravir (Isentress) for the treatment of homo immunodeficiency virus-1 (human immunodeficiency virus-1). It received further comm shutdownation on December 2011 for exercising in pediatric patients ages 2-18. Raltegravir contains raltegravir potassium, a HIV-1 integrase strand transfer inhibitor. It is think to be used in combination with devil both(prenominal) other antiretroviral drugs, one peptidase inhibitor and one non-nucleoside reverse transcriptase inhibitor. The chemical substance phone for raltegravir potassium is: N-[(4-Fluorophenyl)methyl]-1,6-dihydro-5-hydroxy-1-methyl-2-[1-methyl-1-[[(5-methyl-1,3,4-oxadiazol-2-yl) carbonyl] amino]ethyl]-6-oxo-4-pyrimidinecarboxamide monopotassium salt. HIV-1 success uprighty replicates in the human proboscis by utilizing three enzymes: reverse transcriptase, integrase, and protease. Its action cycle initiates with presentation into innkeeper immune cells that express find CD4. Infection is initiated by the selective binding of CD4 receptors with the viral outdoor envelope glycoprotein (gp120). This induces conformational changes on the HIV tissue layer that appropriate for the recognition of chemokine receptors on the guide ara cell.

The interaction in the midst of chemokine receptors and the HIV membrane at last leads to membrane fusion. After foundation into the host cell, the HIV-1 reverse transcriptase converts the hotshot stranded viral RNA into double-stranded desoxyribonucleic acid (cDNA). At this point, integrase binds to the cDNA, creating a pre-integration complex, and transports it into the nucleus. The integration of the viral cDNA into the host genome involves two steps, two of which are catalyzed by the integrase enzyme. First, two nucleotides from the 3end are excised from the nascent HIV-1 DNA. This is followed by the covalent insertion of viral DNA into the host DNA. The integrase-mediated strand...If you necessitate to get a full essay, smart set it on our website: Ordercustompaper.com

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